ME_VADESPAM works well for me, I've seen a few FPs on the rule, but they all occurred in a single 4 day period in December, so I'm willing to put that down to teething problems.
Scoring it at 5.0 is not saying that anything that hits the rule will be treated as spam, if you have a well-trained Bayes most of your ham should have a negative score.
VADE is a full spam filter in its own right; IMO it doesn't make any sense to score it below 4.2 or it can't help with spams that go though SA hitting nothing but BAYES_50.
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