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One problem I have encountered is that I use an alias, and then someone responds to the alias, but I don't have my email set up to respond using that particular alias, then their system blocks the email address I am using for responses because it is an unknown address. Some people have very tight spam filters that basically only allow emails from known contacts, so if you send from something different than the original alias used you get blocked. Maybe just coincidence, but this has mostly happened to me with businesses I was doing paid work for, so resulted in embarassing delays and communications to reestablish communications about paid projects. Has happened to me more than once and has made me gun shy about using one-off aliases that I don't utilize as full-on send and receive email addresses.
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