Assuming you have keyboard shortcuts enabled, press 'x' (select currently focused message) followed by 'd' (delete) to delete the message quickly I rarely use the mouse for routine email browsing and editing.
As far as I know, you cannot open a message in a new tab using just the keyboard. My own normal workflow is to just open ('o' or enter key) and read messages when ready to do so, deleting them with the 'd' key when done. I find it better to keep messages in the list until ready to read them, or sometimes move them to another folder for later processing ('x' select, followed by 'm' move and first few characters of the folder to move the message to)..
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