Positives: FastMail.FM is the only e-mail I've ever paid for and looks like it will be my last. Why? I don't see any reason to switch. FastMail's simple, clean interface is what I wanted and this service is only going to get better. Lightning fast e-mail and good support also doesn't hurt.
Negatives: I do have to deal with spam with my account. Although I believe it's due to the person who used the userid before me being careless with the address, it is annoying. I also found certain options a bit too complicated for normal users and lacked detailed explanation in the help/FAQ area.
I've tried both Runbox and MailSnare and those are good services. But FastMail is just one step ahead in my book.
FastMail.FM...simply GR8.
Tony