One big difference I noticed in the past is that POBox.com is based in Philadelphia and Fastmail in Australia so depending on where you are in the world you might find major differences in response time by customer service. I am not 100% certain if they still do this, but in the recent past POBox.com answered actual emails from customers and potential customers instead of using a ridiculous ticket system like Fastmail. Ticket systems always delay response times and I find them infuriating.
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